Survivorship: Late Effects After Radiation for Sarcoma (Extremity)
What is a late effect?
A late effect is a side effect related to a cancer diagnosis or treatment that happens months to years after treatment. Some side effects that you develop during treatment can last for months to years after treatment is completed (for example, fatigue or neuropathy). These are often called long-term side effects.
Late effects can be health issues or psychological, emotional, and practical challenges.
Late Effects After Radiation for Sarcoma (of the extremity)
Side effects from radiation treatment are directly related to the area of the body being treated. Any area in the treatment field can be damaged, causing side effects. As radiation techniques have improved over the years, the risk of late effects has decreased.
Damage to the Bones
Radiation can cause small cracks (fractures) in the bones that are in the treatment field. Try to avoid trauma including falls or accidents. If you do get hurt, ask your provider if you need an x-ray to check for bone damage.
Survivors who received radiation to the chest or underarm area can experience damage to the brachial plexus nerve. This damage is often caused by scar tissue in the area pressing on the nerves or interrupting the blood supply to the muscles served by these nerves.
- Radiation injury to the nerves and muscles is called radiation-induced neuropathy or radiation fibrosis. It tends to develop in the years following treatment and slowly worsens over time.
- Symptoms can include pain, loss of strength, decreased feeling (sensation), loss of coordination, or loss of movement or function of the muscle. The area affected will depend on the area that was in the radiation field.
- If you develop any of these issues, report them to your provider. Some of these concerns can be caused by other health issues, so your provider will need to figure out the cause.
- If radiation fibrosis is the cause, you may benefit from seeing a cancer rehabilitation physician or physiatrist, and physical or occupational therapists. These specialists can help manage symptoms through therapy, medications, and assistive devices.
If you did not have an amputation, you may be at risk for lymphedema. Surgery to remove lymph nodes or radiation to lymph nodes can cause damage to the lymph nodes and lead to lymphedema. Lymphedema is swelling that can happen in the genital area, belly, buttocks, legs or feet after treatment. It can cause pain, be disfiguring, make activity difficult, and increase the risk of infection in the area.
- Talk to your provider if you are having any new swelling. A Certified Lymphedema Therapist should be consulted at the first sign of swelling to try to keep the lymphedema from worsening.
- You are at risk of infection in any area with lymphedema or area that is at risk for lymphedema. If you have any signs of infection, contact your care team right away or go to the emergency room. These signs include a sudden increase in swelling, an increase in pain, redness, the area is warm to the touch, or fever.
- You should see a Certified Lymphedema Therapist (CLT) at the first sign of swelling to try to keep the lymphedema from worsening.
Radiation can lead to permanent changes in the skin.
- You may develop new scars or notice changes in the color or texture of your skin. Radiation can also change the color and texture of your hair or can cause permanent hair loss in the treated area.
- The soft tissue and muscles under the skin can develop scarring and/or shrinkage, which can lead to a loss of flexibility and movement or chronic swelling in this area.
- You may develop chronic or recurring ulcers of the skin in the area treated. Blood vessels of the skin may become dilated and more visible, although this is not harmful.
- If the skin feels tight or sore, you can apply vitamin E to the skin.
- Use fragrance and dye-free soaps and moisturizers in the area if your skin is sensitive after radiation.
After radiation, the skin in the treated area is more sensitive to sunlight. This sensitivity will last for your lifetime. Practice sun safety, use plenty of sunscreen, wear a wide-brimmed hat, and keep skin in the treated area covered with clothing. Try to avoid being out in the sun between the hours of 10 am-4 pm when it is the strongest.
If you notice any new or worsening skin issues anywhere on your body, you should contact your provider for an assessment.
Managing Late Effects
If you experience any concerning or lasting symptoms, contact your care team. Some side effects require specialized care from healthcare providers experienced in working with cancer survivors. Interdisciplinary survivorships clinics are available at many cancer centers. If a clinic is not available near you, talk with your oncology care team about resources for managing your late effects.
After treatment, talk with your oncology team about receiving a survivorship care plan, which can help you manage the transition to survivorship and learn about life after cancer. You can create your own survivorship care plan using the OncoLife Survivorship Care Plan.
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Koontz, B. F. (2017). Radiation Therapy Treatment Effects: An Evidence-based Guide to Managing Toxicity. Springer Publishing Company.
National Lymphedema Network, https://lymphnet.org/
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