Colorectal Cancer Screening
There are about 150,000 new cases of colorectal cancer diagnosed in the United States each year. The risk of being diagnosed with colon cancer is greatly increased if you hve a family history of colorectal cancer, especially in the well-defined inherited cases of familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC).
Colorectal cancer happens when an adenomatous polyp or pre-cancerous growth forms from the normal tissue lining the colon. This process can take 10-15 years or longer to occur. Many people have no symptoms of this polyp growth. Some may have symptoms such as bleeding, weight loss, or a change in bowel habits.
Your chance of having a polyp or cancer goes up as you get older, especially for those in their 50s-80s. It is important to detect polyp(s) before they become cancerous and/or to detect cancer in its earliest stage. When colorectal cancers are detected in the earliest stage, the five-year survival rate is 90%.
How can we find these pre-cancerous polyps or early cancers? With screening tests. There are a few tests used to screen for colorectal cancers. Patient preference, test availability, and cost all play a role in choosing the best test for a person. It is important to talk with your health care provider about when to start routine screening and what method may be best for you given your risk factors. The American Cancer Society (ACS), the US Multi-Society Task Force on Colorectal Cancer (USMSTF), and the American College of Radiology have developed guidelines for screening, utilizing the available tests including when and how often to perform them. Let’s review what tests are available, how they are performed, and how well they work.
Screening with Stool Testing
Stool testing is broken into two groups; those that test for the presence of blood and those that identify abnormal DNA present in cancer or precancerous polyps. One limitation of both of these types of tests is they are not good at detecting the smaller, pre-cancerous polyps than other available tests can detect. They are most successful in detecting cancer or larger, advanced polyps (polyps on their way to cancer).
Fecal Occult Blood Testing
The least expensive method of colorectal cancer (CRC) screening is the fecal occult blood test (FOBT). These tests take a sample of stool and using a chemical solution, detect if there is blood in the stool. The test seems simple enough, but there are a few guidelines. These restrictions decrease the chance of having a false-positive result.
- You cannot take aspirin and NSAID products (ibuprofen, Naprosyn) for 7 days prior to testing.
- Dietary restrictions include avoiding vitamin C, iron, eating red meat, and some raw vegetables (including broccoli, beets, bananas) for 3 days prior to testing.
- The test must be performed on two or three consecutive bowel movements and repeated every year to be most useful.
If the test is positive, you must be willing to undergo a colonoscopy to find and treat the cause of the positive test. While some providers will perform an FOBT at the time of a rectal exam, this is considered ineffective and is not supported by the ACS or the USMSTF. In addition, the reliability of stool blood testing varies greatly from one brand of test to another and is also affected by the procedure used to process the test.
Fecal Immunochemical Test
FIT (fecal immunochemical test) is a test that uses a different technique to detect blood in the stool. The test is more specific for human blood and it is not affected by diet. You will not need to follow the dietary restrictions mentioned above. The test costs more than FOBT and it is not clear yet if it is better. While it appears that 2 FIT test results are better detection than 1, the optimal number of tests per year is not yet known.
Stool testing for blood is certainly better than no screening at all. However, the concern is that advanced adenomas or early cancers are unlikely to bleed all the time. You may have a negative test even though there is cancer in your colon. The tests must be done more than once and repeated each year in order to have the best chance of detecting cancer. These tests are less effective in detecting tumors on the right side of the colon than on the left. This is important to note because studies have found that over 50% of cancers are found on the right side of the colon in women and on the left side in men.
Stool DNA Testing
The third type of stool test, called sDNA, detects the DNA changes that occur in the bowel when cancer or adenomas are present. These cells contain abnormal DNA, which is continuously shed from the lining of the bowel and passed in the stool. Since each CRC can contain different DNA changes, the test looks for a number of abnormalities but does not detect all the possible DNA changes found in different people, so some tumors go undetected. While the stool blood detection tests use a small sample of stool, sDNA requires the entire stool specimen to be submitted for testing using a customized collection kit from the company.
Some patients will receive a false-positive result using this type of testing and no cancer will be found on further testing. The significance of a false positive result is not yet known. This may be the result of a cancer being present, but not detected, on colonoscopy or possibly a cancer in another area of the gastrointestinal tract (small bowel, stomach, etc.). Studies are being done to figure out how well this test detects adenomas (pre-cancers), though it appears to be far less sensitive for these. The test is also less sensitive in detecting tumors on the right side of the colon than on the left. As with FOBT, if you have a positive sDNA test you will need to have to have a diagnostic colonoscopy performed.
Screening with Endoscopy
Endoscopy uses a camera on the end of a thin, flexible tube to navigate the bowel and look for any polyps or tumors. There are two types of endoscopy used for colorectal cancer screening, sigmoidoscopy, and colonoscopy.
The sigmoidoscope is a slender, flexible tube that has the ability to view about 1/3 of the colon (the left side). If a polyp or tumor is detected with this test, some providers are able to perform a biopsy with sigmoidoscopy, while others must refer the patient for a full colonoscopy and biopsy. If an adenomatous polyp is found during flexible sigmoidoscopy, then a colonoscopy is recommended because of the increased risk of an adenoma on the right side of the colon. It is then recommended that future screening tests be done with colonoscopy. Flexible sigmoidoscopy requires less bowel prep than colonoscopy (2 enemas) and does not require sedation, therefore it may be performed in a provider’s office and does not require recovery time. The test is only as good as the person performing it (their training and adherence to guidelines for the test) and the preparation of the patient (a poorly done bowel prep will limit the sensitivity of the test). Although rare, the main risk of sigmoidoscopy is perforation of the bowel, which can occur with or without a biopsy. When used for CRC screening, the ACS and USMSTF recommend sigmoidoscopy be performed every 5 years.
The colonoscope is similar to the sigmoidoscope, but is longer and can view the whole colon (left and right sides). If a polyp is found, the provider can remove it using a cutting tool that is in the scope and send it to a pathology lab to determine if it is adenomatous (precancerous). Colonoscopy is thought to be the gold standard of colorectal cancer screening but is only as good as the endoscopist performing the test. Given the slow growth of polyps, it is recommended that a normal exam (in the general population) be repeated every 10 years. Those at higher risk (i.e. family history, prior test with polyps, personal history of ulcerative colitis, HNPCC, or FAP) should be screened more frequently.
To prepare for colonoscopy you must clean out your bowel. To do this, you must follow a low fiber, clear liquid diet for one to two days prior and perform a bowel cleansing, which is done with oral laxative solutions or tablets. Your provider will give you specific instructions. Don’t let the fear of the prep keep you from getting your colonoscopy!
During the test, the bowel is filled with air to allow the endoscopist to look at the colon. You will likely need sedation, so you will need to have someone pick you up and take you home after the procedure. You will likely need to take the day off from work. The main risks of colonoscopy are bleeding after the removal of a polyp and perforation of the bowel.
Those considered to be at increased risk for future findings have either 3 or more adenomas, high-grade dysplasia, villous features, or an adenoma 1 cm or larger in size. It is recommended by the USMSTF that they have a 3-year follow-up colonoscopy, with subsequent colonoscopy intervals dependent on those results. Those at lower risk can have a follow-up in 5 to 10 years, Those with hyperplastic polyps should only have a 10-year follow-up as average-risk individuals. More frequent screening is recommended for people with suspected or proven genetic syndromes (HNPCC and FAP). It is unclear how a family history without a genetic syndrome should affect screening intervals.
Additional Screening Tests
Virtual colonoscopy (VC), a method of viewing the colon from outside the body, uses a CT scan. Throughout the procedure, the patient is lying on a table that passes through a donut-like machine that takes pictures from different angles around the body. The 2-dimensional images of the colon are converted by a computer to three-dimensional images and then reviewed by a trained radiologist or gastroenterologist. Some imaging software can interpret the scan into a "fly-through" view, which looks on the screen a lot like what is seen with traditional colonoscopy (TC).
Though the actual time in the scanner is only about 10 minutes, the entire test takes about 30 minutes, including reading and interpretation, which does add to the cost of the procedure. In order for these images to be accurate, patients must undergo bowel prep similar to TC (dietary restrictions and oral laxatives), but for the virtual scan, the bowel may need to be a bit clearer. This is because in a TC, the provider can clear away any stool that is left behind but they cannot do this with VC. You will also drink a contrast medium the night before your test. This helps the provider to tell the difference between stool that is leftover in the colon and polyps.
A tube is inserted into the rectum and air or carbon dioxide is pumped into the colon. This happens just before the CT to expand the colon so that it can be more clearly seen. In some centers, patients are given an intravenous medication called glucagon, causing the bowel walls to relax and improve visualization, but this is now less common. No sedation is used, so patients do not need any recovery time, but some report more discomfort than TC.
VC appears to be quite good at detecting cancers and larger polyps. Some providers have suggested that smaller polyps are less likely to progress to cancer, and therefore the decreased ability to detect them may not be significant. VC is less able to detect flat lesions (also called non-polypoid lesions), which do have the risk of progressing to cancer.
As with most colorectal cancer screening tests, it is only as good as the operator and many of the studies were performed with the best equipment and well-trained radiologists, which may overestimate how good the test is in general. If polyps are detected, you may be referred for TC for polyp removal and biopsy.
There is a very small risk of bowel perforation while air is pumped into the bowel. There is concern among some experts about the lifetime dose of radiation received during this and other radiology exams, but this risk is not yet well understood. Because the test is a CT scan and includes other areas of the abdomen, findings outside the colon may require further workup. As a screening method, VC should begin for average-risk individuals at age 50. How often you should have this test has not been studied, but it is often recommended the test be done every 5 years.
Double Contrast Barium Enema
The double-contrast barium enema (DCBE) is done by placing a small tube into the rectum and coating the inside of the colon with barium (a contrast agent) and pumping in air to distend the colon. X-rays are then taken in different positions to look at the lining of the colon. The patient does need to undergo bowel preparation, similar to that used with traditional colonoscopy, with diet changes and oral laxatives. No sedation is used for the procedure and patients may experience discomfort during or after the test, which takes 20 to 40 minutes. The test does look at the entire colon and appears able to detect most cancers and a majority of significant polyps, though formal clinical studies have not been done. The test may be a good option for people in whom a colonoscopy could not be completed (i.e. due to a blockage) or was contraindicated.
If a polyp greater than 5mm is detected, a colonoscopy is needed to biopsy this finding. As with many colorectal cancer screening tests, the test is only as good as the radiologists performing and reading the test, and the patient’s bowel preparation. Because the colon is being looked at from the outside, stool remnants can be mistaken for polyps or conceal other findings. The test is safe, though bowel perforation remains a low risk. The use of the DCBE has decreased over the past decade, with the test being largely replaced with colonoscopy. When used for colorectal cancer screening, it is recommended that the DCBE be performed every 5 years in average-risk adults over 50 years of age.
There are guidelines for colorectal cancer screening developed by the ACS and the USPSTF (US Preventive Services Task Force). People of average risk should begin screening at age 45 according to the ACS and the USPSTF Keep in mind that the best screening test is one that is actually done. You should talk with your provider about your options and their recommendations based on your personal risk factors, preference, and insurance coverage/cost.
- Flexible sigmoidoscopy, performed every 5 years.
- Colonoscopy, performed every 10 years.
- Double-contrast barium enema, performed every 5 years.
- CT colonography (virtual colonoscopy), performed every 5 years.
- Fecal occult blood test (FOBT), performed every year.
- Fecal immunochemical test (FIT), performed every year.
- Stool DNA test (sDNA), performed every 3 years.
If your baseline screening detects polyps or cancer you will need to plan with your provider how often you should be tested and which test is best. You should discuss your personal risk with your provider, but the following factors increase risk and therefore increase the screening recommendations:
- Personal history of an adenomatous polyp or colorectal cancer.
- Presence of inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
- If a family member has had colorectal cancer or adenomatous polyps, and if so, how many polyps and at what age. First-degree relatives are most important in risk. assessment (parent, sibling, child). Screening generally begins 10 years prior to the age of the relative’s diagnosis.
- If the family has a known or suspected genetic syndrome (HNPCC or FAP).
The best way to prevent colon cancer is through proper screening. It is important to work with your care providers to determine what test will work best for you, how it is covered by your health insurance, and what to do if abnormalities are detected.
American Cancer Society: Colorectal Cancer. Feb 2018. Found at: https://www.cancer.org/cancer/colon-rectal-cancer/detection-diagnosis-staging/acs-recommendations.html
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Imperiale, TF et al. (2014). Multitarget Stool DNA Testing for Colorectal-Cancer Screening. The New England Journal of Medicine. 370:1287-1297.
National Cancer Institute at the National Institutes of Health. (2016). Tests to Detect Colorectal Cancer and Polyps. Found at: http://www.cancer.gov/types/colorectal/screening-fact-sheet
National Cancer Institute at the National Institutes of Health. Cancer Stat Facts: Colorectal Cancer. Found at: https://seer.cancer.gov/statfacts/html/colorect.html
Lieberman, D et al. (2012) Guidelines for colonoscopy surveillance after screening and polypectomy: a concensus update for the US Multi-society task force on colorectal cancer. Gastroenterology. 143:844-857.