All About Myelodysplastic Syndromes (MDS)
What is Myelodysplastic Syndrome (MDS)?
MDS is a group of diseases in which blood cells are affected. The blood cells may be abnormal or the body may not make enough of them. It is a disease of the blood cells and bone marrow. Stem cells are immature cells, found in the bone marrow, that mature to form the many parts of blood. There are three main types of cells that make up your blood:
- Red blood cells (also known as erythrocytes), which carry inhaled oxygen from the lungs to other organs, and carry carbon dioxide from the organs to the lungs to be exhaled.
- Platelets (also known as thrombocytes), which help make clots to stop bleeding.
- White blood cells (also known as leukocytes), which are made up of granulocytes, lymphocytes, and monocytes, each of which has a different role in the immune system. There are 2 types of lymphocytes, B and T lymphocytes.
In MDS, the stem cells do not mature the way that they should and create immature versions of these cells in the blood. The immature cells are called blasts. In some cases, MDS transforms into a more aggressive cancer, such as acute leukemia.
What causes MDS and am I at risk?
The exact number of new cases of MDS each year is not known. It is estimated that about 10,000 new cases of MDS are diagnosed in the United States each year. It occurs more often in the elderly, with the average age at diagnosis being 70. It is expected that the number of people with MDS will continue to grow as the population ages. MDS occurs slightly more often in men than in women.
Previous treatment with certain chemotherapy medications can increase the risk of developing MDS. These medications include (but are not limited to) mechlorethamine, procarbazine, chlorambucil, etoposide, teniposide, cyclophosphamide, ifosfamide, and doxorubicin. This risk is increased if radiation was used in combination with these chemotherapy medications. The number of people who develop this "secondary" or treatment-related MDS is actually very small given the number of people who receive those chemotherapy medications. A history of receiving an autologous bone marrow transplant (BMT) may also increase the risk for secondary MDS.
Certain chemical exposures, such as pesticides, solvents (such as benzene), petroleum, and tobacco smoke can also increase the risk of developing MDS
There are at least 15 gene abnormalities that may indicate a predisposition for MDS, as well as Acute Myelogenous Leukemia (AML) and Myeloproliferative neoplasms (MPN). Your care team may recommend genetic screening and counseling if there is a strong family history of these genetic abnormalities. These include Shwachman-Diamond syndrome, Diamond Blackfan anemia, familial platelet disorder, Fanconi anemia, and severe congenital neutropenia.
Though rare, MDS can occur in children, with an average age of 6 at diagnosis. There are two types of MDS that occur in children: juvenile myelomonocytic leukemia and monosomy-7 syndrome. Children with either of these diseases can present with an increased white blood cell count with a decreased red blood cell and platelet count. The spleen may be enlarged and the skin may be involved as well. There may also be an increase in antibody production (polyclonal gammopathy).
How can I prevent MDS?
There are not any specific interventions that can prevent MDS. Many of the risk factors can not be avoided, such as aging. Generally, if someone has cancer requiring chemotherapy or radiation, it is difficult to avoid using these agents without compromising the treatment of the cancer. One way to lessen the risk of developing MDS is to avoid exposure to known carcinogenic substances such as pesticides, solvents, and tobacco smoke.
What screening tests are available for MDS?
There is not a specific test for MDS. Routine blood work can be used as a screen to check the red and white blood cell counts, and the platelet count, as well as their appearance under a microscope. These tests can help with the diagnosis of MDS and prompt further, more invasive testing, such as a bone marrow biopsy.
What are the signs of MDS?
People with MDS often have no symptoms. Often, people feel fine and the only signs of MDS is a change in blood values. When people do have symptoms, it is most often related to a low red blood cell count (anemia). Sixty percent of people will be anemic and 26% will have bruising or other signs of a low platelet count. Less than 5% of people will have a low white blood cell count or platelet count without anemia.
Symptoms of anemia include pale skin or mucous membranes (i.e. gums), fatigue, chest pain, and dizziness. People may also develop symptoms related to a decrease in the platelet or white blood cell count, such as infections (decreased white blood cell count), and easy bruising or bleeding (low platelet count). Another sign of a low platelet count is petechiae. They are small red or purple spots under the skin that are caused by bleeding. Infections are due to both low white blood cell counts as well as the white blood cells not working correctly. Bacterial infections are most common and they may respond slowly to antibiotics.
Other problems with the immune system can also occur in people with MDS. Some people with MDS have autoimmune-related symptoms (where the body’s immune system attacks normal tissues). This can include damage to normal blood vessels (vasculitis), heart (pericarditis), skin, eyes (iritis), muscles (myositis), nerves (peripheral neuropathy) and red blood cells (pure red blood cell aplasia). Autoimmune diseases such as Raynaud's phenomenon and Sjogren’s disease have been associated with MDS, but it does not appear that one causes the other. Generally, the autoimmune syndrome will resolve with immunosuppressant medications, but treatment with these agents may increase the risk for infection.
Other symptoms, which tend to develop late in the course of MDS, can include fevers and weight loss. Remember, all of these symptoms can be related to a variety of causes, so it is important to see your healthcare provider if you are having these symptoms.
How is MDS diagnosed?
People with MDS often have mild symptoms (or no symptoms) and laboratory tests are many times the first sign that something is wrong. These include:
Complete Blood Count (CBC)
A CBC is done using blood drawn from a vein. A CBC counts the number of red blood cells, platelets, and white blood cells. The amount of hemoglobin, the substance that carries oxygen in red blood cells, and a breakdown of the various types of white blood cells can also be checked with a CBC. Decreased white blood cell counts can be seen (leukopenia) and specifically, the cells which fight bacterial infection (neutrophils), can be decreased in some patients with MDS.
Peripheral Blood Smear
A small sample of blood can be smeared on a slide and looked at to help count cells, as well as examine them for defects.
Anemia is commonly seen in MDS. The body’s normal response to anemia is to form new blood cells (by increasing the production of immature red blood cells known as reticulocytes) and this response may be poor in people with MDS. Reticulocytes can be counted to see if the body is responding appropriately to the low red blood cell count. Red blood cells may appear normal in MDS on a peripheral smear, but oftentimes they have defects including odd shapes, indicating a problem in the production of the red blood cells. In 8% of patients, the defects in the red blood cell shape appear similar to those seen in alpha thalassemia, another disease that affects red blood cells. Defects in red blood cell development may also be detected in bone marrow biopsies, which can aid in diagnosis.
Defects in the appearance of the white blood cells can also be seen on a peripheral blood smear. These defects cause white blood cells to not work well, impacting the immune system function and increasing the risk of developing an infection.
Bone Marrow Biopsy
In MDS, the bone marrow often has more cells than are normally seen (called hypercellular marrow). This increase in cells can be in one cell line or multiple cell lines. For example, an increase in the number of megakaryocytes, which will go on to form platelets in the blood, can be seen. About 25% of people with MDS will have low platelets on a CBC. This can occur because though there is an increase in the number of megakaryocytes, many will die prior to maturing into platelets. In some cases, there is a decrease in the number of cells in the bone marrow (called hypocellular marrow).
There are a number of specific terms that pathologists use to describe findings seen on a blood smear or bone marrow biopsy:
- Auer Rods are made up of granules that accumulate in a rod-like pattern that can be seen in white blood cell blasts. They are most commonly associated with Acute Myeloid Leukemia.
- Blasts are immature blood cells.
- Monocytes are a normal part of the immune system that can ingest (phagocytize) substances that are foreign to the body. They can go on to form macrophages when they exit the blood, which also plays an important role in ingesting foreign substances (such as bacteria). Elevated monocyte counts can indicate a number of disease states including MDS.
- Sideroblasts and Ringed Sideroblasts: When a stain for iron is used on bone marrow biopsy specimens, deposits of iron may be seen in red blood cells and these deposits are called sideroblasts. If a large amount of iron is seen, then they are called ringed sideroblasts. This usually occurs due to a defect in the formation of hemoglobin, which is located in red blood cells.
A number of special studies can be done to help with the diagnosis of MDS:
- Iron Staining: for detecting sideroblasts (described above).
- Periodic Acid Schiff (PAS) Staining: a stain to detect defects in red blood cell maturation.
- Peroxidase/Sudan Black: can be used to help determine if a blast is part of the white blood cell line.
- Esterase Stain: Can be used to detect abnormal white blood cells.
- Cytogenetic Studies: Examination of the chromosomes to check for genetic defects.
- Iron, B12 and folate levels: These are essential building blocks for red blood cells and determining if your body has adequate levels of these are important in people who are anemic.
- Serum erythropoietin (EPO) levels: EPO stimulates the bone marrow to produce more red blood cells. Low levels of EPO may be a contributing factor for anemia.
The WHO Classifications of MDS
After diagnostic tests are complete, the healthcare team will have a better understanding of the subtype of MDS present. The first classification of different subtypes of MDS was proposed by the FAB (French-American-British Group) in 1976 and was revised in 1982. In 2001 and 2008, the WHO (World Health Organization) utilized the FAB as a framework to further refine MDS classifications. In 2016, The WHO classification was once again refined. The WHO classification categorizes the subtypes of MDS based on the results of both blood tests and bone marrow biopsy results.
2016 WHO Classification of MDS
MDS with single lineage dysplasia (MDS-SLD)
Single of bicytopenia
Dysplasia in >10 of one cell line, <5% blasts
MDS with ring sideroblasts (MDS-RS)
Anemia, no blasts
>15% of erythroid precursors w/ring sideroblasts, or >5% of ring sideroblasts, <5% blasts
MDS with multilineage dysplasia (MDS-MLD)
Cytopenia(s), <1 or 109/L monocytes
Dysplasia in >10 of cells in >2 hematopoietic lineages, + 15% ring sideroblasts, <5% blasts
MDS with excess blasts-1 (MDS-EB-1)
Cytopenia(s), <2%-4% blasts, <1 x 109/L monocytes
Unilineage or multilineage dysplasia, 5%–9% blasts, no Auer rods
MDS with excess blasts-2 (MDS-EB-2)
Cytopenia(s), 5%-19% blasts, <1 x 109/L monocytes
Unilineage or multilineage dysplasia, 10%–19% blasts, + Auer rods
MDS, unclassifiable (MDS-U)
Cytopenia(s), +1% blasts on at least 2 occasions
Unilineage dysplasia or no dysplasia but characteristic MDS cytogenics, <5% blasts
MDS with isolated del(5q)
Anemia, platelets normal or increased
Unilineage erythroid dysplasia, isolated del(5q), <5%blasts
Refractory Cytopenia of childhood
Cytopenias, <2% blasts
Dysplasia in 1-3 lineages, <5% blasts
MDS is also classified as primary or secondary. Primary is more common and is used when the cause is not known. Secondary MDS occurs due to damage caused by chemotherapy or radiation therapy. This may also be called “treatment-associated MDS” and it can be more difficult to treat.
The International Working Group for the Prognosis of MDS (IWG-PM) has also developed a tool, called the International Prognostic Scoring System (IPSS-R), to help clinicians estimate prognosis and risk of MDS progression to acute leukemia. This tool includes measures of hemoglobin levels, absolute neutrophil count (ANC), platelets, bone marrow blast percentage, and cytogenetic category to produce a score and category that can help estimate clinical outcomes and treatment planning. Additionally, the age at diagnosis and how generally healthy the person is at the time of diagnosis are taken into account when selecting a therapy. Your care team will discuss how this scoring system is applied to your case and how it may potentially impact your treatment plan.
What are the treatments for MDS?
Treatment decisions for MDS are centered on a variety of factors, but two goals remain clear:
- Symptom management related to decreased blood counts.
- Decrease the risk of progression of this disease to acute leukemia and improve overall survival.
Given that most people present with MDS at an older age and that MDS is a chronic disease, supportive care is extremely important to limit symptoms of MDS and maintain a high quality of life. These treatments include:
Blood Products and Growth Factors
Transfusions of red blood cells may be used to treat symptoms of anemia, such as fatigue and shortness of breath. Frequent transfusions can cause large amounts of iron to buildup in the body, causing damage to organs such as the liver, pancreas, and heart. Iron chelation therapy is used to bind up the iron so that it can be removed from the body through the urine. If your platelet count is low, you may be given platelet transfusions.
Growth factors are medications used to help promote blood cell production. Epoetin alfa and darbepoetin alfa can be used to help maintain red blood cell counts without transfusions. Filgrastim, pegfilgrastim, and sargramostim can be used to promote white blood cell counts. Romiplostim and eltrombopag are being studied to see if these medications can help with low platelet counts in patients with MDS.
Lenalidomide is an immunomodulating drug that works well in low-grade MDS. It has been found to work well in people with 5q-syndrome, though it also appears to work in some people with other types of MDS. It can help eliminate the need for blood transfusions for a period of time.
Antithymocyte globulin (ATG) is an immune suppressant that has been useful in the treatment of certain subtypes of MDS in people under the age of 60. It is given through an intravenous (IV) infusion in the hospital. It is given in the hospital because it can cause severe allergic reactions. ATG may be given with cyclosporine, which also can suppress the immune system.
There are a variety of chemotherapy options available for the treatment of MDS and the intensity of the chemotherapy treatment depends on the goals of therapy, the patient’s health and their IPSS score. Low-intensity chemotherapy medications include azacitidine and decitabine. These medications may decrease the risk of MDS transforming into leukemia and in some patients may improve survival. High-intensity chemotherapy is similar to the chemotherapy used in the treatment of acute leukemia. High-intensity chemotherapy medications include those used low-intensity regimens and cytarabine, daunorubicin and idarubicin may be used.
Stem Cell Transplants
Allogeneic stem cell transplants (where the bone marrow comes from a donor) can be used to treat MDS. This is the only potential cure for people with MDS and is generally used for people in good health, who are younger than 60, and who have a matched donor.
Even after transplant, MDS can relapse. Donor leukocyte infusions (DLI) in combination with azacitidine chemotherapy can be used in the treatment of relapsed MDS post-transplant depending on cytogenetics, comorbidities, and age.
There are clinical research trials for most types of cancer, and every stage of the disease. Clinical trials are designed to determine the value of specific treatments. Trials are often designed to treat a certain stage of cancer, either as the first form of treatment offered or as an option for treatment after other treatments have failed to work. They can be used to evaluate medications or treatments to prevent cancer, detect it earlier, or help manage side effects. Clinical trials are extremely important in furthering our knowledge of disease. It is through clinical trials that we know what we do today, and many exciting new therapies are currently being tested. Talk to your provider about participating in clinical trials in your area. You can also explore currently open clinical trials using the OncoLink Clinical Trials Matching Service.
Resources for more Information
Aplastic Anemia and MDS International Foundation
Provides disease and treatment information and support resources.
Provides disease and treatment information for healthcare professionals and patients/caregivers.
Leukemia and Lymphoma Society
Provides disease information and support resources.
Leukemia Research Foundation
Provides disease information and a glossary of medical terms related to leukemia.
American Cancer Society. MDS.
NCCN Guidelines. Myelodysplastic Syndromes.
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